Article provided by: bosterbio.com
Tau proteins are useful in the study of memory-related diseases. They are particularly abundant in the central nervous system. Bosterbio Antibody and ELISA offers quality and fast tau antibody to help researchers examine the impact of this essential compound.
What does the Tau Protein do?
These proteins stabilize microtubules. They are expressed in the central nervous system as well as in low levels in astrocytes and oligodendrocytes.
Tau proteins function to modulate the stability of axonal microtubules as well as flexibility. Tau is present in dendrites and is active mainly in the distal parts of axons.
Tau in learning and the brain
Tau proteins are a factor in major learning tasks. They are present in the axons as a multi-faceted protein providing support and flexibility. The compound facilitates habituation and negatively regulates long-term memory. Tau positively influences non-associative learning.
In brain development, studies of knock out mice show no abnormalities. This raises the possibility that other MAPS perform the same function.
Where is the MAPT gene located?
The gene responsible for encoding tau is located on chromosome 17q21 containing 16 exons. The brain encodes tau through 11 exons. Tau itself is not present in dendrites but in the axons where stabilization and flexibility are required.
Tau protein is a highly soluble MAPT protein. The presence in the distal portions of exons contrasts directly with MAP6 proteins, which lock down microtubules as well as MAP2 proteins stabilizing microtubules.
Mutations to the Tau protein may result in tangles of paired helical filaments and straight filaments. These filaments are involved in the pathogenesis of Alzheimer’s, dementia, and multiple other tauopathies.
Tau protein directly affects the breakdown of the living cell caused by the tangles forming from blocked nerve synapses. A clump of the compound blocks essential nutrients from reaching the brain, causing the related cells to die.
When are high levels of tau protein present?
An overabundance of the protein is not only present in Alzheimer’s but traumatic brain injury as well. Researchers linked high levels of tau directly to poor recovery after brain trauma. The resulting tangles block critical nutrients from reaching brain cells and allowing for regeneration and repair.
Repetitive mild traumatic brain injury may lead to chronic traumatic encephalopathy or CTE. Fibral tangles of tau are a common part of CTE. Successive concussions increase the speed of cognitive decline from the overabundance of the compound.
How does the tau antibody help?
The tau antibody helps reduce the presence of the protein. This allows researchers to create new therapies and study the effects that tangles have in different diseases related to the central nervous system.
If you are looking for significant quantities of high-quality antibodies, Bosterbio Antibody and ELISA offers the kits you need to push your research forward. Our tau protein antibody offerings are available for research and manufacturing.
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